Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31319295 | 0.77 | NOS3 (0.38) | NPC1RAB9AL3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL1278237 | 0.77 | NOS3 (0.38) | NPC1RAB9AL3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL29479488 | 0.76 | KDM4E (0.33) | HPGDNPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL29382435 | 0.76 | CYP2C9 (0.40) | HPGDALDH1A1NPC1L3MBTL1CYP1A2 | |
| SCHEMBL28786384 | 0.76 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL1671404 | 0.76 | CYP2D6 (0.32) | NPC1L3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL29782963 | 0.76 | CYP2D6 (0.32) | NPC1L3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL15913345 | 0.76 | KDM4E (0.33) | HPGDNPC1RAB9AL3MBTL1CYP1A2 | |
| SCHEMBL729066 | 0.76 | CYP2C9 (0.40) | HPGDALDH1A1NPC1L3MBTL1CYP1A2 | |
| SCHEMBL31200955 | 0.75 | TSHR (0.40) | HPGDALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858900-A1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006097691-A1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-09-21 | — | — | WO | disclosed |