SCHEMBL5280179

SCHEMBL5280179

CC(C)(C=O)Cc1cccc(Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.51
CHRM1 P11229 1/20 0.51
CHRM3 P20309 1/20 0.51
PNMT P11086 2/20 0.46
CYP3A4 P08684 3/20 0.45
MEN1 O00255 1/20 0.45
USP2 O75604 1/20 0.45
ALDH1A1 P00352 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2D6 P10635 1/20 0.45
MAPT P10636 1/20 0.45
TSHR P16473 1/20 0.45
MAPK1 P28482 1/20 0.45
BLM P54132 1/20 0.45
KMT2A Q03164 1/20 0.45
ATM Q13315 1/20 0.45
HIF1A Q16665 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
TAAR1 Q96RJ0 3/20 0.43
RIPK1 Q13546 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29845719 0.80 MEN1 (0.46) CYP3A4MEN1USP2ALDH1A1CYP1A2
SCHEMBL1659997 0.80 MAPT (0.46) CHRM2CHRM1CHRM3CYP3A4MEN1
SCHEMBL1697989 0.80 MEN1 (0.46) CYP3A4MEN1USP2ALDH1A1CYP1A2
SCHEMBL73643 0.79 PNMT (0.54) CHRM2PNMTCYP3A4ALDH1A1TSHR
SCHEMBL27794492 0.79 ALDH1A1 (0.45) PNMTCYP3A4MEN1USP2ALDH1A1
SCHEMBL9163007 0.79 CYP1A2 (0.45) CYP3A4MEN1USP2ALDH1A1CYP1A2
SCHEMBL14775953 0.79 ALDH1A1 (0.45) CYP3A4MEN1USP2ALDH1A1CYP1A2
Ammonia Solution, Strong SCHEMBL27962080 0.77 PNMT (0.52) CHRM2PNMTCYP3A4TSHRTAAR1
SCHEMBL4328568 0.77 SLC6A4 (0.55) CYP3A4MEN1USP2ALDH1A1CYP1A2
SCHEMBL96457 0.77 TAAR1 (0.52) CYP3A4MEN1USP2ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2233512-B1 POLYTHIOETHERIMIDES AND METHOD FOR PRODUCING THEREOF NINGBO INST MATERIALS TECHNOLOGY & ENG CAS (CN) 2013-03-20 EP claimed
CN-101146773-A 6, 7, 8, 9-tetrahydro-5-amino-5h-benzocyclohepten-6-ol derivatives and related compounds used as anti-inflammatory agents BAYER SCHERING PHARMA AG (DE) 2008-03-19 CN disclosed
EP-1863765-A1 6, 7, 8, 9-TETRAHYDRO-5-AMINO-5H-BENZOCYCLOHEPTEN-6-OL DERIVATIVES AND RELATED COMPOUNDS USED AS ANTI-INFLAMMATORY AGENTS Bayer Schering Pharma Aktiengesellschaft (DE) 2007-12-12 EP disclosed
WO-2006100099-A1 6, 7, 8, 9-TETRAHYDRO-5-AMINO-5H-BENZOCYCLOHEPTEN-6-OL DERIVATIVES AND RELATED COMPOUNDS USED AS ANTI-INFLAMMATORY AGENTS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2006-09-28 WO disclosed