Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5292438 | 0.93 | RAB9A (0.43) | SMN1; SMN2NPC1LMNARAB9AKMT2A | |
| SCHEMBL2294694 | 0.84 | MAPT (0.47) | NPC1LMNARAB9AKMT2AKDM4E | |
| SCHEMBL2295362 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1LMNARAB9AKMT2A | |
| SCHEMBL2296479 | 0.82 | NPC1 (0.39) | SMN1; SMN2NPC1LMNARAB9AKMT2A | |
| SCHEMBL2291245 | 0.82 | RAB9A (0.38) | SMN1; SMN2NPC1LMNARAB9AKMT2A | |
| SCHEMBL2294482 | 0.80 | NAMPT (0.48) | SMN1; SMN2NPC1LMNARAB9AKMT2A | |
| SCHEMBL5295936 | 0.79 | MAPT (0.41) | SMN1; SMN2NPC1LMNARAB9AKMT2A | |
| SCHEMBL5291502 | 0.79 | BCHE (0.46) | SMN1; SMN2NPC1LMNARAB9AKMT2A | |
| SCHEMBL2292264 | 0.79 | NPC1 (0.44) | SMN1; SMN2NPC1LMNARAB9AKMT2A | |
| SCHEMBL2295598 | 0.79 | MEN1 (0.43) | SMN1; SMN2NPC1LMNARAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |