Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | SELP | P16109 | 1/20 | 0.39 |
| ▸ | SELE | P16581 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5295744 | 0.93 | BCHE (0.46) | BCHEACHENAMPTSELPSELE | |
| SCHEMBL2294482 | 0.90 | NAMPT (0.48) | NAMPTNR1I2ITGB1ITGA4NPC1 | |
| SCHEMBL5289524 | 0.90 | ITGB1 (0.44) | BCHEACHEITGB1ITGA4LMNA | |
| SCHEMBL5305927 | 0.90 | BCHE (0.51) | BCHEACHEITGB1ITGA4LMNA | |
| SCHEMBL2298594 | 0.89 | KMT2A (0.46) | NAMPTMCHR1ITGB1ITGA4NPC1 | |
| SCHEMBL2294562 | 0.88 | MAPT (0.44) | NAMPTNR1I2ITGB1ITGA4NPC1 | |
| SCHEMBL5289381 | 0.88 | ITGB1 (0.44) | NAMPTITGB1ITGA4NPC1RAB9A | |
| SCHEMBL2295665 | 0.86 | PSEN1 (0.45) | NAMPTITGB1ITGA4NPC1RAB9A | |
| SCHEMBL2292763 | 0.85 | MAPT (0.50) | MCHR1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL2294711 | 0.85 | ALDH1A1 (0.47) | NAMPTLMNASMN1; SMN2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |