Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | TACR1 | P25103 | 2/20 | 0.48 |
| ▸ | TACR2 | P21452 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 10/20 | 0.47 |
| ▸ | ACHE | P22303 | 6/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5280288 | 1.00 | KMT2A (0.51) | KMT2AMEN1TACR1TACR2BCHE | |
| SCHEMBL5280165 | 0.93 | BCHE (0.49) | KMT2ATACR1TACR2BCHEACHE | |
| SCHEMBL5282971 | 0.89 | BCHE (0.47) | BCHEACHE | |
| SCHEMBL5282975 | 0.89 | BCHE (0.47) | BCHEACHE | |
| SCHEMBL5282166 | 0.85 | ACHE (0.53) | KMT2AMEN1BCHEACHE | |
| SCHEMBL5282667 | 0.84 | BCHE (0.55) | KMT2AMEN1TACR1BCHEACHE | |
| SCHEMBL5289480 | 0.84 | BCHE (0.56) | KMT2ATACR1BCHEACHE | |
| SCHEMBL5291489 | 0.82 | BCHE (0.52) | KMT2AMEN1TACR1BCHEACHE | |
| SCHEMBL5278655 | 0.82 | BCHE (0.59) | BCHEACHE | |
| SCHEMBL27621272 | 0.80 | KCNA5 (0.59) | KMT2AMEN1TACR1TACR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | claimed |
| EP-1863804-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2007-12-12 | — | — | EP | disclosed |
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | KMT2A 30/4885MEN1 2348/4885TACR1 3952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.