Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 2/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12421965 | 0.68 | KMT2A (0.46) | SMN1; SMN2ATMKMT2ALMNAALDH1A1 | |
| SCHEMBL4009843 | 0.65 | SMN1; SMN2 (0.49) | SMN1; SMN2ATMKMT2ALMNAALDH1A1 | |
| SCHEMBL4004231 | 0.65 | SMN1; SMN2 (0.47) | SMN1; SMN2ATMKMT2ALMNAALDH1A1 | |
| SCHEMBL2291129 | 0.64 | ATM (0.44) | SMN1; SMN2ATMKMT2ALMNAALDH1A1 | |
| SCHEMBL2297391 | 0.64 | ATM (0.44) | SMN1; SMN2ATMKMT2ALMNAALDH1A1 | |
| SCHEMBL4003758 | 0.64 | ROCK2 (0.51) | SMN1; SMN2ATMKMT2ALMNAALDH1A1 | |
| SCHEMBL12420935 | 0.63 | ATM (0.43) | SMN1; SMN2ATMKMT2ALMNAALDH1A1 | |
| SCHEMBL10155060 | 0.63 | BACE1 (0.63) | — | |
| SCHEMBL2295833 | 0.61 | ALDH1A1 (0.74) | SMN1; SMN2ATMKMT2AALDH1A1KDM4E | |
| SCHEMBL13359488 | 0.61 | ATM (0.53) | SMN1; SMN2ATMKMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | disclosed |