Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.51 |
| ▸ | PTGES | O14684 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014165 | 0.82 | LTB4R (0.67) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL14229905 | 0.81 | LTB4R (0.56) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL4453600 | 0.80 | LTB4R (0.55) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL4449671 | 0.80 | LTB4R (0.55) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL9533718 | 0.79 | LTB4R (0.54) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL4450404 | 0.79 | BCHE (0.55) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL4880111 | 0.78 | CA12 (0.45) | ALOX5POLBLMNAMAPTHTT | |
| SCHEMBL4453618 | 0.77 | BCHE (0.52) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL7835952 | 0.77 | LTB4R (0.52) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL7063146 | 0.77 | STAT5B (0.47) | PTGESPOLBCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851208-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006074950-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2006-07-20 | — | — | WO | disclosed |