Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.52 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7825818 | 0.90 | LTB4R (0.51) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL1846485 | 0.89 | MEN1 (0.44) | ALOX5L3MBTL1 | |
| SCHEMBL4453600 | 0.87 | LTB4R (0.55) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL4449671 | 0.87 | LTB4R (0.55) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL4450404 | 0.86 | BCHE (0.55) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL8542129 | 0.84 | PTGER1 (0.47) | BCHEL3MBTL1 | |
| SCHEMBL4453618 | 0.84 | BCHE (0.52) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL9533718 | 0.84 | LTB4R (0.54) | LTB4RLTB4R2ALOX5FFAR1FFAR4 | |
| SCHEMBL4289433 | 0.83 | L3MBTL1 (0.44) | ALOX5L3MBTL1 | |
| SCHEMBL3014165 | 0.82 | LTB4R (0.67) | LTB4RLTB4R2ALOX5FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815105-B1 | HETEROCYCLIC SUBSTITUTED PIPERAZINONE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | AVENTIS PHARMA INC (US) | 2001-10-04 | — | — | EP | disclosed |
| US-5864045-A | Heterocyclic substituted piperazinone derivatives | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-26 | — | — | US | disclosed |
| US-5840726-A | Heterocyclic substituted piperazinone derivatives | HOECHST MARION ROUSSEL INC. (US) | 1998-11-24 | — | — | US | disclosed |
| EP-0815105-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINONE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028441-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINONE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-09-19 | — | — | WO | disclosed |