Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.67 |
| ▸ | CA3 | P07451 | 1/20 | 0.67 |
| ▸ | CA4 | P22748 | 1/20 | 0.67 |
| ▸ | CA6 | P23280 | 1/20 | 0.67 |
| ▸ | CA5A | P35218 | 1/20 | 0.67 |
| ▸ | CA7 | P43166 | 1/20 | 0.67 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.67 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.67 |
| ▸ | CA9 | Q16790 | 1/20 | 0.67 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.67 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.67 |
| ▸ | CTSS | P25774 | 4/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | CTSK | P43235 | 5/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12232470 | 0.90 | CA12 (0.53) | CA12CA1CA2CA3CA4 | |
| SCHEMBL18721571 | 0.89 | CA12 (0.71) | CA12CA1CA2CA3CA4 | |
| SCHEMBL13583868 | 0.89 | CA12 (0.71) | CA12CA1CA2CA3CA4 | |
| SCHEMBL13583863 | 0.89 | CA12 (0.71) | CA12CA1CA2CA3CA4 | |
| SCHEMBL13449159 | 0.87 | CTSS (0.50) | CA12CA1CA2CA3CA4 | |
| SCHEMBL2233396 | 0.86 | CA12 (0.71) | CA12CA1CA2CA3CA4 | |
| SCHEMBL2236257 | 0.86 | CA12 (0.71) | CA12CA1CA2CA3CA4 | |
| SCHEMBL2303306 | 0.85 | CA12 (0.70) | CA12CA1CA2CA3CA4 | |
| SCHEMBL2303305 | 0.85 | CA12 (0.70) | CA12CA1CA2CA3CA4 | |
| SCHEMBL15569270 | 0.84 | CTSS (0.57) | CTSSCTSLCTSKCTSBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160031801-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2016-02-04 | — | — | US | disclosed |
| US-9108902-B2 | Deuterated 2-amino-3-hydroxypropanoic acid derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2015-08-18 | — | — | US | disclosed |
| US-20140221492-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2014-08-07 | — | — | US | disclosed |
| US-8704001-B2 | Deuterated 2-amino-3-hydroxypropanoic acid derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| EP-2598476-A1 | PROCESS FOR PREPARATION OF LACOSAMIDE AND SOME N-BENZYL-PROPANAMIDE INTERMEDIATE DERIVATIVES | Indoco Remedies Limited (IN) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012014226-A1 | PROCESS FOR PREPARATION OF LACOSAMIDE AND SOME N-BENZYL-PROPANAMIDE INTERMEDIATE DERIVATIVES | INDOCO REMEDIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |
| US-20110251131-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221492-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | GRIN3A, GRIK5, GRIN2A | CA12 663/4885CA1 125/4885CA2 285/4885 |
| US-20110251131-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | GRIN3A, GRIK5, GRIN2A | CA12 663/4885CA1 125/4885CA2 285/4885 |
| US-20160031801-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | GRIN3A, GRIK5, GRIN2A | CA12 663/4885CA1 125/4885CA2 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.