SCHEMBL5281305

SCHEMBL5281305

NC(Cc1c(Cl)[nH]c2ccccc12)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.54
MAPT P10636 2/20 0.54
MEN1 O00255 1/20 0.54
LMNA P02545 1/20 0.54
MPO P05164 1/20 0.54
TSHR P16473 1/20 0.54
BLM P54132 1/20 0.54
PMP22 Q01453 1/20 0.54
KMT2A Q03164 1/20 0.54
HIF1A Q16665 1/20 0.54
EGFR P00533 4/20 0.49
SRC P12931 2/20 0.49
SCN9A Q15858 1/20 0.49
ALPI P09923 1/20 0.47
PKM P14618 1/20 0.47
PTGS1 P23219 1/20 0.47
XIAP P98170 1/20 0.47
SLC7A5 Q01650 1/20 0.47
ALDH1A1 P00352 2/20 0.43
GAA P10253 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7688917 1.00 KDM4E (0.54) KDM4EMAPTMEN1LMNAMPO
SCHEMBL8653746 1.00 KDM4E (0.54) KDM4EMAPTMEN1LMNAMPO
SCHEMBL31599467 1.00 KDM4E (0.54) KDM4EMAPTMEN1LMNAMPO
SCHEMBL497627 0.84 KDM4E (0.55) KDM4EMAPTMEN1LMNAMPO
SCHEMBL2263891 0.84 KDM4E (0.55) KDM4EMAPTMEN1LMNAMPO
SCHEMBL471925 0.84 KDM4E (0.55) KDM4EMAPTMEN1LMNAMPO
SCHEMBL7694812 0.84 KDM4E (0.55) KDM4EMAPTMEN1LMNAMPO
SCHEMBL6295317 0.84 KDM4E (0.55) KDM4EMAPTMEN1LMNAMPO
SCHEMBL29415605 0.84 KDM4E (0.55) KDM4EMAPTMEN1LMNAMPO
SCHEMBL12838301 0.83 KDM4E (0.51) KDM4EMAPTMEN1LMNAMPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108026162-A Cystine knot scaffold platform 豪夫迈·罗氏有限公司 2018-05-11 CN claimed
WO-2025111511-A2 REVERSIBLY REACTIVE AFFINITY SELECTION MASS SPECTROMETRY AND USES THEREOF CALICO LIFE SCIENCES LLC (US) 2025-05-30 WO disclosed
US-20250057861-A1 HALOGENATED PSILOCYBIN DERIVATIVES AND METHODS OF USING Enveric Biosciences Canada Inc. (CA) 2025-02-20 US disclosed
US-20240417764-A1 METHODS FOR THE PRODUCTION OF TRYPTOPHANS, TRYPTAMINES, INTERMEDIATES, SIDE PRODUCTS AND DERIVATIVES MIAMI UNIVERSITY 2024-12-19 US disclosed
US-12138276-B2 Halogenated psilocybin derivatives and methods of using Enveric Biosciences Canada Inc. (CA) 2024-11-12 US disclosed
US-20240299427-A1 HALOGENATED PSILOCYBIN DERIVATIVES AND METHODS OF USING Enveric Biosciences Canada Inc. (CA) 2024-09-12 US disclosed
EP-4426676-A2 METHODS FOR THE PRODUCTION OF TRYPTOPHANS, TRYPTAMINES, INTERMEDIATES, SIDE PRODUCTS AND DERIVATIVES MIAMI UNIVERSITY (US) 2024-09-11 EP disclosed
US-11998557-B2 Halogenated psilocybin derivatives and methods of using Enveric Biosciences Canada Inc. (CA) 2024-06-04 US disclosed
WO-2023081837-A9 METHODS FOR THE PRODUCTION OF TRYPTOPHANS, TRYPTAMINES, INTERMEDIATES, SIDE PRODUCTS AND DERIVATIVES MIAMI UNIVERSITY (US) 2024-03-14 WO disclosed
US-20230293558-A1 HALOGENATED PSILOCYBIN DERIVATIVES AND METHODS OF USING MAGICMED INDUSTRIES INC. (CA) 2023-09-21 US disclosed
WO-2023081837-A2 METHODS FOR THE PRODUCTION OF TRYPTOPHANS, TRYPTAMINES, INTERMEDIATES, SIDE PRODUCTS AND DERIVATIVES MIAMI UNIVERSITY (US) 2023-05-11 WO disclosed
WO-2022047579-A1 HALOGENATED PSILOCYBIN DERIVATIVES AND METHODS OF USING MAGICMED INDUSTRIES INC. (CA) 2022-03-10 WO disclosed
WO-2007002594-A1 COSMETIC COMPOSITIONS AND METHODS USING TRANSFORMING GROWTH FACTOR-BETA MIMICS BHATNAGAR RAJENDRA S (US) 2007-01-04 WO disclosed
WO-2007002469-A2 THERAPEUTIC COMPOSITIONS AND METHODS USING TRANSFORMING GROWTH FACTOR-BETA MIMICS BHATNAGAR RAJENDRA S (US) 2007-01-04 WO disclosed
US-20060293227-A1 Cosmetic compositions and methods using transforming growth factor-beta mimics BHATNAGAR RAJENDRA S 2006-12-28 US disclosed
US-20060293228-A1 Therapeutic compositions and methods using transforming growth factor-beta mimics BHATNAGAR RAJENDRA S 2006-12-28 US disclosed
US-6774212-B2 FOR THERAPY OF VIRAL INFECTION OR AS AN ASSAY STANDARD OR REAGENT BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-08-10 US disclosed
US-20020123468-A1 Alpha-ketoamide inhibitors of hepatitis C virus NS3 protease BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-09-05 US disclosed
EP-0707490-A1 NEUROPEPTIDE Y ANTAGONISTS AND AGONISTS UNIVERSITY OF CINCINNATI (US) 1996-04-24 EP disclosed
WO-1995000161-A1 NEUROPEPTIDE Y ANTAGONISTS AND AGONISTS UNIVERSITY OF CINCINNATI (US) 1995-01-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12138276-B2 Halogenated psilocybin derivatives and methods of using CES2, MAOB, CNR1 KDM4E 3792/4885MAPT 3922/4885MEN1 3615/4885
US-20240299427-A1 HALOGENATED PSILOCYBIN DERIVATIVES AND METHODS OF USING CES2, MAOB, CNR1 KDM4E 3792/4885MAPT 3922/4885MEN1 3615/4885
US-20230293558-A1 HALOGENATED PSILOCYBIN DERIVATIVES AND METHODS OF USING CES2, MAOB, CNR1 KDM4E 3792/4885MAPT 3922/4885MEN1 3615/4885
US-11998557-B2 Halogenated psilocybin derivatives and methods of using CES2, MAOB, CNR1 KDM4E 3792/4885MAPT 3922/4885MEN1 3615/4885
US-20250057861-A1 HALOGENATED PSILOCYBIN DERIVATIVES AND METHODS OF USING CES2, MAOB, CNR1 KDM4E 3792/4885MAPT 3922/4885MEN1 3615/4885
US-20020123468-A1 Alpha-ketoamide inhibitors of hepatitis C virus NS3 protease CES1, CYP51A1, SPINT2 KDM4E 643/4885MAPT 3370/4885MEN1 4642/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.