SCHEMBL5281408

SCHEMBL5281408

CCCn1nnc(C#N)c1C

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC9A1 P19634 1/20 0.37
ALDH1A1 P00352 4/20 0.33
GRM2 Q14416 1/20 0.33
CYP1A2 P05177 1/20 0.33
MAPK1 P28482 1/20 0.33
CTSK P43235 5/20 0.32
HPGD P15428 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
TOP2A P11388 1/20 0.32
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
KMT2A Q03164 1/20 0.32
KDM4E B2RXH2 1/20 0.31
USP2 O75604 1/20 0.31
ADORA2A P29274 1/20 0.31
ADORA2B P29275 1/20 0.31
CYP17A1 P05093 1/20 0.30
GRIA4 P48058 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5277783 0.89 SLC9A1 (0.40) SLC9A1ALDH1A1GRM2MAPK1HPGD
SCHEMBL5277477 0.86 SLC9A1 (0.43) SLC9A1ALDH1A1GRM2MAPK1MAPT
SCHEMBL5277049 0.84 MAOA (0.38) SLC9A1ALDH1A1GRM2MAPK1HPGD
SCHEMBL5285694 0.81 GRM2 (0.40) SLC9A1ALDH1A1GRM2CYP1A2CTSK
SCHEMBL5279348 0.81 SLC9A1 (0.37) SLC9A1ALDH1A1GRM2CYP1A2CTSK
SCHEMBL5277800 0.81 SLC9A1 (0.37) SLC9A1ALDH1A1GRM2CYP1A2CTSK
SCHEMBL5288377 0.79 SLC9A1 (0.36) SLC9A1ALDH1A1GRM2CYP1A2CTSK
SCHEMBL5280172 0.79 GRIA4 (0.39) SLC9A1ALDH1A1GRM2MAPK1CTSK
SCHEMBL5280517 0.79 SLC9A1 (0.36) SLC9A1ALDH1A1GRM2CTSKHPGD
SCHEMBL5281984 0.77 SLC9A1 (0.34) SLC9A1ALDH1A1GRM2CTSKHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1859781-A2 Brightening and/or colouring agent with triazoles Henkel Kommanditgesellschaft auf Aktien (DE) 2007-11-28 EP disclosed