Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.49 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.49 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.49 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | GRM6 | O15303 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL406002 | 0.85 | MAPT (0.54) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL5291433 | 0.85 | MAPT (0.54) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL25176657 | 0.79 | MAPT (0.49) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL19175062 | 0.79 | VCAM1 (0.44) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL1343684 | 0.79 | MAPT (0.49) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL1344102 | 0.79 | VCAM1 (0.56) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL2870229 | 0.79 | VCAM1 (0.44) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL34462079 | 0.79 | MAPT (0.45) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL26426493 | 0.79 | MAPT (0.45) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL773066 | 0.78 | VCAM1 (0.49) | MAPTGRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697304-B1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | LILLY CO ELI (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2007135417-A1 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-11-29 | — | — | WO | disclosed |
| US-20070082907-A1 | Peroxisome proliferator activated receptor modulators | ELI LILLY AND COMPANY (IN) | 2007-04-12 | — | — | US | disclosed |
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082907-A1 | Peroxisome proliferator activated receptor modulators | PPARG, PPARA, PPARD | MAPT 3161/4885GRIA1 363/4885GRIA2 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.