Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.54 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.54 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.54 |
| ▸ | GRM6 | O15303 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | VCAM1 | P19320 | 6/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4614436 | 0.86 | VCAM1 (0.47) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL25176657 | 0.85 | MAPT (0.49) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3294262 | 0.85 | MAPT (0.49) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL10306700 | 0.85 | VCAM1 (0.56) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL5281459 | 0.85 | MAPT (0.49) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL28458967 | 0.85 | TDP1 (0.51) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL34462079 | 0.81 | MAPT (0.45) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL26426493 | 0.81 | MAPT (0.45) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL16664635 | 0.81 | MAPT (0.45) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL3293721 | 0.79 | ALDH1A1 (0.47) | MAPTGRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545154-B2 | Herbicides | BAYER AKTIENGESELLSCHAFT (DE) | 2003-04-08 | — | — | US | claimed |
| US-20030040626-A1 | Method for the production of N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides and new intermediate products | HUPPERTS ACHIM (DE) | 2003-02-27 | — | — | US | claimed |
| EP-1003718-A1 | METHOD FOR THE PRODUCTION OF N-(5-AMINO-2-CYANO-4-FLUORO-PHENYL)-SULPHONAMIDES AND NEW INTERMEDIATE PRODUCTS | BAYER AG (DE) | 2000-05-31 | — | — | EP | claimed |
| WO-1999005098-A1 | METHOD FOR THE PRODUCTION OF N-(5-AMINO-2-CYANO-4-FLUORO-PHENYL)-SULPHONAMIDES AND NEW INTERMEDIATE PRODUCTS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-02-04 | — | — | WO | claimed |
| JP-7070041-A | — | — | None | — | — | JP | disclosed |
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | ALCON RESEARCH, LTD (US) | 2012-03-15 | — | — | US | disclosed |
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | ALCON RESEARCH, LTD (US) | 2012-03-15 | — | — | US | disclosed |
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | ALCON RESEARCH, LTD (US) | 2012-03-15 | — | — | US | disclosed |
| US-20110257137-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| US-20110257137-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| US-20110257137-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2011112731-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-09-15 | — | — | WO | disclosed |
| WO-2010030785-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS INC. (US) | 2010-03-18 | — | — | WO | disclosed |
| EP-1003718-B1 | METHOD FOR THE PRODUCTION OF N-(5-AMINO-2-CYANO-4-FLUORO-PHENYL)-SULPHONAMIDES | BAYER CROPSCIENCE AG (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-6545154-B2 | Herbicides | BAYER AKTIENGESELLSCHAFT (DE) | 2003-04-08 | — | — | US | disclosed |
| US-20030040626-A1 | Method for the production of N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides and new intermediate products | HUPPERTS ACHIM (DE) | 2003-02-27 | — | — | US | disclosed |
| US-6310206-B1 | 2-AMINO-4,5-DIFLUORO-BENZONITRILE IS REACTED A SULPHONYL HALIDES; N-(2-CYANO-4,5-DIFLUORO-PHENYL)-SULPHONAMIDES (CLAIMED AS INTERMEDIATES) OBTAINED IN THE FIRST STEP ARE AMINATED WITH AMMONIA | BAYER AKTIENGESELLSCHAFT (DE) | 2001-10-30 | — | — | US | disclosed |
| EP-1003718-A1 | METHOD FOR THE PRODUCTION OF N-(5-AMINO-2-CYANO-4-FLUORO-PHENYL)-SULPHONAMIDES AND NEW INTERMEDIATE PRODUCTS | BAYER AG (DE) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999005098-A1 | METHOD FOR THE PRODUCTION OF N-(5-AMINO-2-CYANO-4-FLUORO-PHENYL)-SULPHONAMIDES AND NEW INTERMEDIATE PRODUCTS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-02-04 | — | — | WO | disclosed |
| JP-H0770041-A | 3,4-DIFLUORO-6-NITROBENZONITRILE | IHARA CHEM IND CO LTD | 1995-03-14 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH3, HRH2 | MAPT 2336/4885GRIA1 540/4885GRIA2 695/4885 |
| US-20030040626-A1 | Method for the production of N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides and new intermediate products | PFAS, SRM, NISCH | MAPT 3031/4885GRIA1 3848/4885GRIA2 3388/4885 |
| US-20110257137-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH3, HRH2 | MAPT 2336/4885GRIA1 540/4885GRIA2 695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.