Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 7/20 | 0.62 |
| ▸ | GSTM2 | P28161 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 8/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.57 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.57 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3506038 | 0.86 | MAPT (0.59) | GSTP1GSTM2MAPTLMNAKMT2A | |
| SCHEMBL18878890 | 0.79 | GSTP1 (0.77) | GSTP1GSTM2MAPTKMT2AHTT | |
| SCHEMBL137897 | 0.78 | MAPT (0.71) | MAPTLMNAKMT2AHTTPKM | |
| SCHEMBL29405540 | 0.78 | MAPT (0.71) | MAPTLMNAKMT2AHTTPKM | |
| SCHEMBL5244464 | 0.77 | GSTP1 (0.63) | GSTP1GSTM2MAPTLMNAKMT2A | |
| SCHEMBL13236138 | 0.77 | MAPT (0.60) | MAPTLMNAKMT2AHTTPKM | |
| SCHEMBL6836307 | 0.77 | GSTP1 (1.00) | GSTP1GSTM2MAPTKMT2AHTT | |
| SCHEMBL10752315 | 0.77 | MAPT (0.63) | MAPTLMNAKMT2AHTTPKM | |
| SCHEMBL11366224 | 0.76 | MAPT (0.69) | MAPTLMNAKMT2AHTTPKM | |
| SCHEMBL13355661 | 0.74 | MAPT (0.66) | MAPTLMNAKMT2AHTTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758873-A1 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006002284-A1 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | claimed |
| US-20050282818-A1 | Ubiquitin ligase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | claimed |
| US-20050282818-A1 | Ubiquitin ligase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282818-A1 | Ubiquitin ligase inhibitors | NEDD4, TRAF6, XIAP | GSTP1 2061/4885GSTM2 2584/4885MAPT 1681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.