Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 3/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5303016 | 0.93 | GAA (0.46) | GAAKMT2AMEN1CYP3A4F10 | |
| SCHEMBL2296016 | 0.88 | NPC1 (0.50) | KMT2AMEN1F10F2RAB9A | |
| SCHEMBL2297135 | 0.86 | KMT2A (0.46) | KMT2AMEN1F10F2RAB9A | |
| SCHEMBL2291392 | 0.82 | KMT2A (0.51) | GAAKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL2295674 | 0.81 | NPC1 (0.56) | KMT2AMEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2296252 | 0.80 | NR1I2 (0.47) | KMT2AMEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2296670 | 0.80 | NR1I2 (0.47) | KMT2AMEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2299394 | 0.80 | F2 (0.44) | KMT2AMEN1F10F2RAB9A | |
| SCHEMBL2294143 | 0.80 | NPC1 (0.53) | KMT2AMEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5282895 | 0.80 | ALDH1A1 (0.47) | GAAKMT2AMEN1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |