Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.52 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.52 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4093702 | 0.85 | ALK (0.70) | ALKEGFRPLK4LCKFYN | |
| SCHEMBL4089503 | 0.79 | ALK (0.70) | ALKEGFRPLK4LCKFYN | |
| SCHEMBL4100115 | 0.79 | ALK (0.63) | ALKEGFRPLK4LCKFYN | |
| SCHEMBL4095865 | 0.79 | ULK1 (0.74) | ALKEGFRPLK4LCKFYN | |
| SCHEMBL4089370 | 0.78 | ALK (0.68) | ALKEGFRPLK4LCKFYN | |
| SCHEMBL4095269 | 0.77 | ALK (0.81) | ALKEGFRPLK4LCKFYN | |
| SCHEMBL4096592 | 0.75 | ZAP70 (0.78) | ALKEGFRPLK4LCKFYN | |
| SCHEMBL5290384 | 0.75 | ZAP70 (0.53) | ALKEGFRPLK4LCKFYN | |
| SCHEMBL4100866 | 0.75 | ALK (0.66) | ALKEGFRPLK4LCKFYN | |
| SCHEMBL4103561 | 0.74 | ULK1 (0.67) | ALKEGFRPLK4LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784392-A2 | PYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2007-05-16 | — | — | EP | claimed |
| WO-2006021454-A2 | PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2006-03-02 | — | — | WO | claimed |