Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.40 |
| ▸ | ACACA | Q13085 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 2/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5349862 | 0.89 | L3MBTL3 (0.46) | L3MBTL3L3MBTL1KDM4EPOLBACACB | |
| SCHEMBL5285662 | 0.84 | CES2 (0.42) | KDM4EALDH1A1CHRM1 | |
| SCHEMBL5331038 | 0.84 | CES2 (0.42) | KDM4EALDH1A1CHRM1 | |
| SCHEMBL5323468 | 0.83 | TP53 (0.41) | KDM4EEPHX2HTTLMNAKMT2A | |
| SCHEMBL5330298 | 0.80 | PTH1R (0.39) | KDM4EALDH1A1 | |
| SCHEMBL5320857 | 0.77 | PTH1R (0.36) | KDM4EALDH1A1CHRM1 | |
| SCHEMBL5319651 | 0.76 | PTH1R (0.37) | KDM4EALDH1A1CHRM1 | |
| SCHEMBL5323429 | 0.76 | CES2 (0.42) | KDM4EALDH1A1CHRM1 | |
| SCHEMBL5329713 | 0.73 | PTH1R (0.45) | KDM4EALDH1A1CHRM1 | |
| SCHEMBL5324581 | 0.73 | CES2 (0.41) | KDM4EALDH1A1LMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |