Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5280483 | 0.90 | RAB9A (0.48) | LMNARAB9AHPGDGAAALDH1A1 | |
| SCHEMBL5281557 | 0.86 | LMNA (0.50) | LMNARAB9AHPGDGAAALDH1A1 | |
| SCHEMBL6037902 | 0.84 | RAB9A (0.50) | LMNARAB9AHPGDGAAALDH1A1 | |
| SCHEMBL6037974 | 0.81 | LMNA (0.59) | LMNAHPGDGAAALDH1A1EPHX2 | |
| SCHEMBL5280810 | 0.81 | LMNA (0.46) | LMNARAB9AHPGDGAAALDH1A1 | |
| SCHEMBL6038163 | 0.81 | LMNA (0.49) | LMNARAB9AHPGDGAAALDH1A1 | |
| SCHEMBL5286752 | 0.80 | RAB9A (0.47) | LMNARAB9AHPGDKMT2A | |
| SCHEMBL5325209 | 0.80 | LMNA (0.51) | LMNARAB9AHPGDGAAALDH1A1 | |
| SCHEMBL5287408 | 0.80 | RAB9A (0.47) | LMNARAB9AHPGDKMT2A | |
| SCHEMBL6037915 | 0.79 | LMNA (0.50) | LMNARAB9AHPGDGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863804-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2007-12-12 | — | — | EP | disclosed |
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | disclosed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | LMNA 851/4885RAB9A 2884/4885HPGD 2248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.