Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | FAAH | O00519 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.56 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3397254 | 0.86 | EPHX2 (1.00) | EPHX2ALDH1A1MEN1KMT2AEPHX1 | |
| SCHEMBL5051924 | 0.86 | EPHX2 (1.00) | EPHX2ALDH1A1MEN1KMT2AEPHX1 | |
| SCHEMBL1800332 | 0.85 | EPHX2 (0.74) | EPHX2ALDH1A1MEN1KMT2AEPHX1 | |
| SCHEMBL2753089 | 0.85 | EPHX2 (0.96) | EPHX2ALDH1A1MEN1KMT2AEPHX1 | |
| Hydrochloric Acid SCHEMBL5047929 | 0.83 | EPHX2 (0.93) | EPHX2ALDH1A1MEN1KMT2AEPHX1 | |
| SCHEMBL5049597 | 0.81 | EPHX2 (0.90) | EPHX2ALDH1A1MEN1KMT2AEPHX1 | |
| SCHEMBL11629518 | 0.81 | EPHX2 (0.70) | EPHX2ALDH1A1MEN1KMT2AMAP4K4 | |
| SCHEMBL12931997 | 0.81 | EPHX2 (1.00) | EPHX2MEN1KMT2AEPHX1NPC1 | |
| Cyclohexylamine SCHEMBL4655542 | 0.80 | EPHX2 (0.65) | EPHX2ALDH1A1MEN1KMT2AMAP4K4 | |
| SCHEMBL11629386 | 0.79 | EPHX2 (0.68) | EPHX2ALDH1A1MEN1KMT2AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2744778-B1 | META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS | UNIV CALIFORNIA (US) | 2019-01-16 | — | — | EP | disclosed |
| US-9745255-B2 | Meta-substituted biphenyl peripherally restricted FAAH inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-29 | — | — | US | disclosed |
| EP-2598477-B1 | PERIPHERALLY RESTRICTED FAAH INHIBITORS | UNIV CALIFORNIA (US) | 2016-03-02 | — | — | EP | disclosed |
| US-9187413-B2 | Peripherally restricted FAAH inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-11-17 | — | — | US | disclosed |
| CN-104203906-A | Meta-substituted biphenyl peripherally restricted FAAH inhibitors | UNIV CALIFORNIA | 2014-12-10 | — | — | CN | disclosed |
| US-20140288170-A1 | META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-09-25 | — | — | US | disclosed |
| EP-2744778-A2 | META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS | The Regents of the University of California (US) | 2014-06-25 | — | — | EP | disclosed |
| US-20130217764-A1 | PERIPHERALLY RESTRICTED FAAH INHIBITORS | UNIVERSITA DEGLI STUDI DI URBINO (IT) | 2013-08-22 | — | — | US | disclosed |
| EP-2598477-A2 | PERIPHERALLY RESTRICTED FAAH INHIBITORS | The Regents of the University of California (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2013028570-A2 | META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-02-28 | — | — | WO | disclosed |
| WO-2012015704-A2 | PERIPHERALLY RESTRICTED FAAH INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217764-A1 | PERIPHERALLY RESTRICTED FAAH INHIBITORS | FAAH, FAAH2, CNR2 | EPHX2 78/4885ALDH1A1 623/4885MEN1 4744/4885 |
| US-20140288170-A1 | META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS | FAAH, FAAH2, CNR2 | EPHX2 201/4885ALDH1A1 278/4885MEN1 4382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.