Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.79 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.65 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.65 |
| ▸ | DRD4 | P21917 | 1/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.65 |
| ▸ | HRH1 | P35367 | 1/20 | 0.65 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.65 |
| ▸ | DRD3 | P35462 | 1/20 | 0.65 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5276311 | 0.88 | ACHE (0.78) | ACHEOPRM1SIGMAR1SLC22A1NR1I2 | |
| SCHEMBL14601860 | 0.88 | ACHE (1.00) | ACHEOPRM1SIGMAR1 | |
| SCHEMBL3094944 | 0.88 | OPRM1 (0.68) | ACHEOPRM1SIGMAR1SLC22A1NR1I2 | |
| Hydrochloric Acid SCHEMBL3089658 | 0.87 | OPRM1 (0.67) | ACHEOPRM1SIGMAR1SLC22A1NR1I2 | |
| SCHEMBL5870718 | 0.87 | ACHE (0.64) | ACHEOPRM1SIGMAR1SLC22A1NR1I2 | |
| SCHEMBL5277560 | 0.85 | ACHE (0.79) | ACHEOPRM1ADRA1AADRA1BOPRD1 | |
| SCHEMBL5279313 | 0.85 | OPRM1 (0.65) | ACHEOPRM1SIGMAR1SLC22A1NR1I2 | |
| SCHEMBL28597364 | 0.84 | OPRM1 (1.00) | ACHEOPRM1SIGMAR1 | |
| SCHEMBL3083010 | 0.81 | OPRM1 (0.65) | OPRM1SIGMAR1SLC22A1NR1I2ABCB1 | |
| SCHEMBL3083237 | 0.81 | OPRM1 (0.59) | ACHEOPRM1SIGMAR1SLC22A1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406623-B1 | SUBSTITUTED 1-PHENETHYLPIPERIDINE COMPOUNDS USED AS INTER ALIA ANALGESICS | GRUENENTHAL GMBH (DE) | 2007-12-12 | — | — | EP | disclosed |