Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 5/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4890730 | 0.95 | LMNA (0.51) | LMNAHTTKDM4EUSP2HPGD | |
| SCHEMBL30890339 | 0.77 | LMNA (0.58) | LMNAHTTKDM4EUSP2HPGD | |
| SCHEMBL31381338 | 0.75 | LMNA (0.59) | LMNAHTTKDM4EUSP2HPGD | |
| SCHEMBL22875307 | 0.72 | KDM4E (0.57) | LMNAHTTKDM4EUSP2HPGD | |
| SCHEMBL25295618 | 0.70 | MAPT (0.67) | LMNAHTTKDM4EHPGDNPSR1 | |
| SCHEMBL31303093 | 0.70 | MAPT (0.67) | LMNAHTTKDM4EHPGDNPSR1 | |
| SCHEMBL4883086 | 0.69 | — | — | |
| SCHEMBL239335 | 0.69 | LMNA (0.55) | LMNAHTTKDM4EUSP2HPGD | |
| SCHEMBL31381165 | 0.69 | LMNA (0.62) | LMNAHTTKDM4ECYP2C19NOTUM | |
| SCHEMBL25197786 | 0.69 | LMNA (0.58) | LMNAHTTKDM4EUSP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008146-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |