Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 10/20 | 0.64 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PTGES | O14684 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL529168 | 0.89 | MAPT (0.55) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL529111 | 0.89 | MAPT (0.64) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL528552 | 0.87 | KDM4E (0.64) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL528853 | 0.87 | MAPT (0.75) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL528278 | 0.86 | MAPT (0.55) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL528306 | 0.86 | KDM4E (0.67) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL529003 | 0.85 | MAPT (0.66) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL528675 | 0.85 | MAPT (0.51) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL527884 | 0.84 | MAPT (0.74) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL527937 | 0.83 | ALDH1A1 (0.48) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |