Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528278 | 0.95 | MAPT (0.55) | MAPTALDH1A1KDM4EHPGDHTT | |
| SCHEMBL529111 | 0.92 | MAPT (0.64) | MAPTALDH1A1KDM4EHPGDHTT | |
| SCHEMBL528291 | 0.89 | KDM4E (0.68) | MAPTALDH1A1KDM4EHPGDHTT | |
| SCHEMBL528675 | 0.88 | MAPT (0.51) | MAPTALDH1A1KDM4EHPGDHTT | |
| SCHEMBL528229 | 0.87 | MAPT (0.62) | MAPTALDH1A1KDM4EHPGDHTT | |
| SCHEMBL528865 | 0.86 | ALDH1A1 (0.54) | MAPTALDH1A1KDM4EHPGDHTT | |
| SCHEMBL528087 | 0.84 | KMT2A (0.55) | MAPTALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL528797 | 0.84 | MAPT (0.51) | MAPTALDH1A1KDM4EHPGDHTT | |
| SCHEMBL528566 | 0.83 | MAPT (0.59) | MAPTALDH1A1KDM4EHPGDHTT | |
| SCHEMBL528670 | 0.82 | MAPT (0.61) | MAPTALDH1A1KDM4EHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | claimed |
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |