Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.78 |
| ▸ | HTT | P42858 | 3/20 | 0.78 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528258 | 0.87 | MAPT (0.59) | MAPTHTTLMNAALDH1A1HPGD | |
| SCHEMBL529586 | 0.87 | MAPT (0.59) | MAPTHTTLMNAALDH1A1HPGD | |
| SCHEMBL528805 | 0.86 | MAPT (0.58) | MAPTHTTLMNAALDH1A1HPGD | |
| SCHEMBL528854 | 0.84 | MAPT (0.56) | MAPTHTTLMNAALDH1A1HPGD | |
| SCHEMBL528208 | 0.84 | ALDH1A1 (0.64) | MAPTHTTLMNAALDH1A1HPGD | |
| SCHEMBL529419 | 0.81 | MAPT (0.61) | MAPTHTTLMNAALDH1A1HPGD | |
| SCHEMBL528383 | 0.79 | NPSR1 (0.65) | MAPTHTTLMNAALDH1A1HPGD | |
| SCHEMBL528449 | 0.79 | ALDH1A1 (0.67) | MAPTHTTLMNAALDH1A1HPGD | |
| SCHEMBL528386 | 0.78 | MAPT (0.53) | MAPTHTTLMNAALDH1A1HPGD | |
| SCHEMBL528646 | 0.78 | ALDH1A1 (0.59) | MAPTHTTLMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |