Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.77 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | MDM4 | O15151 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27616908 | 0.92 | KCNK3 (0.68) | KCNK3KCNK9MAPTHPGDLMNA | |
| SCHEMBL2914620 | 0.89 | KCNK3 (0.68) | KCNK3KCNK9MAPTHPGDLMNA | |
| SCHEMBL2309216 | 0.86 | MAPT (0.63) | KCNK3KCNK9MAPTHPGDLMNA | |
| SCHEMBL7291079 | 0.85 | NR1H4 (0.76) | KCNK3KCNK9MAPTHPGDLMNA | |
| SCHEMBL16532204 | 0.85 | SLC16A3 (0.61) | KCNK3KCNK9MAPTHPGDLMNA | |
| SCHEMBL14492571 | 0.85 | KCNK3 (0.63) | KCNK3KCNK9MAPTHPGDLMNA | |
| SCHEMBL948318 | 0.84 | MAPT (0.59) | KCNK3KCNK9MAPTHPGDLMNA | |
| SCHEMBL11171600 | 0.84 | EPHX1 (0.68) | KCNK3KCNK9MAPTHPGDLMNA | |
| SCHEMBL6971074 | 0.84 | NR1H4 (0.57) | KCNK3KCNK9MAPTHPGDLMNA | |
| SCHEMBL21711305 | 0.84 | NR1H4 (0.75) | KCNK3KCNK9HPGDCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109438348-A | The preparation method and preparation method thereof of one kind (S) -1- phenyl -1,2,3,4- tetrahydroisoquinoline | 凯瑞斯德生化(苏州)有限公司 | 2019-03-08 | — | — | CN | claimed |
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | claimed |
| CN-1155278-A | Arylthio compounds as antibacteral and antiviral agents | WARNER LAMBERT CO (US) | 1997-07-23 | — | — | CN | claimed |
| CN-212283980-U | (S) -1-phenyl-1, 2,3, 4-tetrahydroisoquinoline synthesis reaction kettle | 济南爱思医药科技有限公司 | 2021-01-05 | — | — | CN | disclosed |
| CN-211837857-U | Synthetic suction filter device of solifenacin intermediate component | 济南爱思医药科技有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-110218158-A | A method of photocatalytic synthesis is at amide compound in water phase | 福建医科大学 | 2019-09-10 | — | — | CN | disclosed |
| CN-109438348-A | The preparation method and preparation method thereof of one kind (S) -1- phenyl -1,2,3,4- tetrahydroisoquinoline | 凯瑞斯德生化(苏州)有限公司 | 2019-03-08 | — | — | CN | disclosed |
| CN-109438348-A | The preparation method and preparation method thereof of one kind (S) -1- phenyl -1,2,3,4- tetrahydroisoquinoline | 凯瑞斯德生化(苏州)有限公司 | 2019-03-08 | — | — | CN | disclosed |
| EP-3008045-B1 | ANTIBACTERIAL THIAZOLECARBOXYLIC ACIDS | ANTABIO SAS (FR) | 2018-05-09 | — | — | EP | disclosed |
| US-20170166560-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-06-15 | — | — | US | disclosed |
| US-9617224-B2 | Five-membered heterocycles useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-04-11 | — | — | US | disclosed |
| CN-106279013-A | A kind of method directly being catalyzed and synthesized amide by carboxylic acid and amine | 中国石油大学(北京) | 2017-01-04 | — | — | CN | disclosed |
| WO-2016008862-A1 | SUBSTITUTED VINYL AND ALKYNYL CYANOCYCLOALKANOLS AND VINYL AND ALKYNYL CYANOHETEROCYCLOALKANOLS AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-01-21 | — | — | WO | disclosed |
| US-20150259297-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-09-17 | — | — | US | disclosed |
| US-9079860-B2 | Five-membered heterocycles useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-07-14 | — | — | US | disclosed |
| US-8716492-B2 | Five-membered heterocycles useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-06 | — | — | US | disclosed |
| CN-103159677-A | 1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline preparation method | JINAN SHENGQUAN HEALTANG BIOLOG TECHNOLOGY CO LTD | 2013-06-19 | — | — | CN | disclosed |
| WO-2012139891-A1 | SUBSTITUTED VINYL AND ALKINYL CYCLOHEXENOLS AS ACTIVE AGENTS AGAINST ABIOTIC STRESS IN PLANTS | BAYER CROPSCIENCE AG (DE) | 2012-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166560-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | F12, F11, F5 | KCNK3 342/4885KCNK9 352/4885MAPT 4157/4885 |
| US-20150259297-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | F12, F11, F5 | KCNK3 342/4885KCNK9 352/4885MAPT 4157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.