Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.57 |
| ▸ | MDM4 | O15151 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8902669 | 0.86 | KCNK3 (0.57) | NR1H4KCNK3KCNK9MDM4TP53 | |
| SCHEMBL21711305 | 0.86 | NR1H4 (0.75) | NR1H4KCNK3KCNK9MDM4TP53 | |
| SCHEMBL528445 | 0.84 | KCNK3 (0.77) | NR1H4KCNK3KCNK9MDM4TP53 | |
| SCHEMBL11347943 | 0.83 | NR1H4 (0.55) | NR1H4KCNK3KCNK9MDM4TP53 | |
| SCHEMBL8654405 | 0.82 | KCNK3 (0.57) | NR1H4KCNK3KCNK9MDM4TP53 | |
| SCHEMBL7511265 | 0.82 | HDAC3 (0.61) | NR1H4KCNK3KCNK9MDM4TP53 | |
| SCHEMBL6963256 | 0.81 | NR1H4 (0.60) | NR1H4KCNK3KCNK9MDM4TP53 | |
| SCHEMBL27849340 | 0.81 | KCNK3 (0.56) | NR1H4KCNK3KCNK9MDM4TP53 | |
| SCHEMBL1110180 | 0.80 | MDM4 (0.73) | KCNK3KCNK9MDM4TP53HPGD | |
| SCHEMBL1491952 | 0.79 | KCNK3 (0.55) | NR1H4KCNK3KCNK9MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |