Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.66 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | RXRB | P28702 | 2/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4329559 | 0.82 | HDAC1 (0.77) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL4338759 | 0.80 | HDAC1 (1.00) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL4320653 | 0.79 | HDAC1 (0.68) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL5280959 | 0.76 | HDAC8 (0.56) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL11624937 | 0.76 | HDAC1 (0.51) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL5639177 | 0.76 | NOTUM (0.51) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL18169197 | 0.75 | RXRA (0.76) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL11617789 | 0.72 | HDAC1 (0.51) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL11621352 | 0.70 | HDAC1 (0.49) | HDAC1HDAC2HDAC6HDAC3HDAC8 | |
| SCHEMBL5545105 | 0.69 | HRH3 (0.60) | HDAC1HDAC2HDAC6HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863804-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2007-12-12 | — | — | EP | disclosed |
| EP-1778632-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-05-02 | — | — | EP | disclosed |
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | disclosed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | disclosed |
| WO-2005123673-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | HDAC1 1/4885HDAC2 5/4885HDAC6 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.