Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20652569 | 0.90 | GAA (0.50) | POLBAPEX1GAAHPGDNPC1 | |
| SCHEMBL7979821 | 0.89 | POLB (0.54) | POLBAPEX1GAAHPGDGPR27 | |
| SCHEMBL7979814 | 0.86 | POLB (0.66) | POLBAPEX1GAAHPGDNPC1 | |
| SCHEMBL7981477 | 0.84 | GAA (0.55) | POLBAPEX1GAAHPGDSCN9A | |
| SCHEMBL12506962 | 0.78 | GAA (0.50) | POLBAPEX1GAANPC1RAB9A | |
| SCHEMBL690412 | 0.78 | POLB (0.46) | POLBAPEX1HPGDGPR27NPC1 | |
| SCHEMBL29997409 | 0.78 | POLB (0.46) | POLBAPEX1HPGDGPR27NPC1 | |
| SCHEMBL13687249 | 0.77 | SCN9A (0.43) | GAAHPGDGPR27SMN1; SMN2SCN9A | |
| SCHEMBL12683792 | 0.77 | HPGD (0.51) | POLBAPEX1GAAHPGDNPC1 | |
| SCHEMBL13575596 | 0.77 | GAA (0.48) | POLBAPEX1GAANUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010350-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | PFIZER PRODUCTS INC. (US) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007010350-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | PFIZER PRODUCTS INC. (US) | 2007-01-25 | — | — | WO | disclosed |
| US-20070021634-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | PFIZER INC | 2007-01-25 | — | — | US | disclosed |
| US-20070021634-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | PFIZER INC | 2007-01-25 | — | — | US | disclosed |
| US-20070021634-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | PFIZER INC | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021634-A1 | SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS | DHFR, CYP2F1, EPOR | POLB 2054/4885APEX1 1759/4885GAA 2784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.