Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | GSK3B | P49841 | 6/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20267338 | 0.75 | GSK3B (0.55) | ALDH1A1GSK3BGSK3ANPC1RAB9A | |
| SCHEMBL28522247 | 0.74 | MAPT (0.57) | PARP1ALDH1A1KDM4EGSK3BNPC1 | |
| Hydrochloric Acid SCHEMBL15282882 | 0.73 | MAPT (0.55) | PARP1ALDH1A1KDM4EGSK3BNPC1 | |
| SCHEMBL11033491 | 0.70 | CES1 (0.35) | CES1ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL454828 | 0.70 | POLB (0.51) | PARP1ALDH1A1KDM4EGSK3BLMNA | |
| SCHEMBL11066854 | 0.69 | SMN1; SMN2 (0.41) | ALDH1A1KDM4ENPC1RAB9ALMNA | |
| SCHEMBL11229952 | 0.67 | TLR9 (0.50) | PARP1ALDH1A1KDM4EGSK3BGSK3A | |
| SCHEMBL29010702 | 0.67 | CES1 (0.53) | CES1PARP1ALDH1A1KDM4EGSK3B | |
| SCHEMBL16754925 | 0.66 | GSK3B (0.62) | PARP1ALDH1A1KDM4EGSK3BGSK3A | |
| SCHEMBL18660318 | 0.64 | PARP1 (0.45) | PARP1ALDH1A1KDM4EGSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848363-B1 | TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND | MEDSHINE DISCOVERY INC (CN) | 2023-07-19 | — | — | EP | disclosed |
| EP-3214081-B1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | KANGPU BIOPHARMACEUTICALS LTD (CN) | 2020-07-08 | — | — | EP | disclosed |
| EP-2885303-B1 | DEUTERATED BARICITINIB | CONCERT PHARMACEUTICALS INC (US) | 2018-12-26 | — | — | EP | disclosed |
| US-20150336927-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. | 2015-11-26 | — | — | US | disclosed |
| US-20150336927-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. | 2015-11-26 | — | — | US | disclosed |
| US-9045453-B2 | Substituted dioxopiperidinyl phthalimide derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| US-9045453-B2 | Substituted dioxopiperidinyl phthalimide derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| US-9045453-B2 | Substituted dioxopiperidinyl phthalimide derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| CN-102245023-B | Substituted dioxopiperidinyl phthalimide derivatives | CONCERT PHARMACEUTICALS INC | 2015-05-13 | — | — | CN | disclosed |
| CN-102245023-B | Substituted dioxopiperidinyl phthalimide derivatives | CONCERT PHARMACEUTICALS INC | 2015-05-13 | — | — | CN | disclosed |
| WO-2012015986-A2 | SUBSTITUTED DIOXOPIPERIDINYL PHTALIMIDE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2012-02-02 | — | — | WO | disclosed |
| WO-2012015986-A2 | SUBSTITUTED DIOXOPIPERIDINYL PHTALIMIDE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2012-02-02 | — | — | WO | disclosed |
| US-20110288126-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288126-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| CN-102245023-A | Substituted dioxopiperidinyl phthalimide derivatives | CONCERT PHARMACEUTICALS INC | 2011-11-16 | — | — | CN | disclosed |
| CN-102245023-A | Substituted dioxopiperidinyl phthalimide derivatives | CONCERT PHARMACEUTICALS INC | 2011-11-16 | — | — | CN | disclosed |
| EP-2373165-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-10-12 | — | — | EP | disclosed |
| EP-2373165-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010056344-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIES | CONCERT PHARMACEUTICALS INC. (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056344-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIES | CONCERT PHARMACEUTICALS INC. (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288126-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | NFATC1, PDCD11, IL5 | CES1 3764/4885PARP1 1989/4885ALDH1A1 1306/4885 |
| US-20150336927-A1 | SUBSTITUTED DIOXOPIPERIDINYL PHTHALIMIDE DERIVATIVES | NFATC1, PDCD11, IL5 | CES1 3764/4885PARP1 1989/4885ALDH1A1 1306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.