Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038176 | 0.84 | KDM4E (0.77) | KDM4EMAPTALDH1A1HDAC1HDAC2 | |
| SCHEMBL6038108 | 0.84 | HDAC1 (0.77) | KDM4EMAPTALDH1A1HDAC1HDAC2 | |
| SCHEMBL26493586 | 0.83 | HDAC1 (0.61) | KDM4EMAPTALDH1A1HDAC1HDAC2 | |
| SCHEMBL20289864 | 0.81 | KDM4E (0.49) | KDM4EMAPTALDH1A1HDAC1HDAC2 | |
| SCHEMBL6370146 | 0.80 | KDM4E (0.55) | KDM4EMAPTALDH1A1HDAC1HDAC2 | |
| SCHEMBL20287496 | 0.80 | HDAC1 (0.57) | KDM4EMAPTALDH1A1HDAC1HDAC2 | |
| SCHEMBL20266986 | 0.79 | HRH3 (0.52) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL20287482 | 0.78 | DRD2 (0.63) | KDM4EALDH1A1HDAC1HDAC2HDAC3 | |
| SCHEMBL13753883 | 0.78 | KDM4E (0.77) | KDM4EMAPTALDH1A1HDAC1HDAC2 | |
| SCHEMBL30644782 | 0.76 | LOXL2 (0.49) | KDM4EMAPTALDH1A1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863804-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2007-12-12 | — | — | EP | disclosed |
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | KDM4E 67/4885MAPT 3848/4885ALDH1A1 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.