Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.66 |
| ▸ | HRH2 | P25021 | 1/20 | 0.65 |
| ▸ | HRH1 | P35367 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12062196 | 0.96 | KDM4E (0.70) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL492178 | 0.96 | KDM4E (0.70) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL5283396 | 0.92 | KDM4E (0.64) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL491803 | 0.88 | KDM4E (0.92) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL5855860 | 0.87 | KDM4E (0.90) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL5213285 | 0.87 | KDM4E (0.89) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL6981478 | 0.87 | KDM4E (0.89) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL5278243 | 0.86 | KDM4E (0.75) | KDM4EHRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL4089314 | 0.85 | HRH3 (0.66) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL491823 | 0.85 | HRH3 (0.66) | KDM4EHRH3ALDH1A1SMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863486-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103537-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | disclosed |