Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.89 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.70 |
| ▸ | HRH2 | P25021 | 2/20 | 0.70 |
| ▸ | HRH1 | P35367 | 2/20 | 0.70 |
| ▸ | MAOB | P27338 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.64 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.64 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981478 | 1.00 | KDM4E (0.89) | KDM4EHRH3HRH2HRH1MAOB | |
| SCHEMBL491803 | 0.98 | KDM4E (0.92) | KDM4EHRH3HRH2HRH1MAOB | |
| SCHEMBL5855860 | 0.97 | KDM4E (0.90) | KDM4EHRH3HRH2HRH1MAOB | |
| SCHEMBL490099 | 0.94 | KDM4E (0.80) | KDM4EHRH3MAOBALDH1A1L3MBTL1 | |
| SCHEMBL5856201 | 0.93 | KDM4E (0.78) | KDM4EHRH3MAOBALDH1A1L3MBTL1 | |
| SCHEMBL6534752 | 0.92 | KDM4E (0.77) | KDM4EHRH3ALDH1A1L3MBTL1PSMB1 | |
| SCHEMBL12193816 | 0.91 | KDM4E (0.80) | KDM4EHRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL6052612 | 0.88 | KDM4E (0.71) | KDM4EHRH3MAOBALDH1A1L3MBTL1 | |
| SCHEMBL7250762 | 0.87 | KDM4E (0.70) | KDM4EHRH3HRH2HRH1MAPT | |
| SCHEMBL9530115 | 0.87 | ALDH1A1 (0.81) | KDM4EHRH3HRH2HRH1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301480-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-04-16 | — | — | EP | claimed |
| WO-2002006223-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2002-01-24 | — | — | WO | claimed |
| EP-1301480-B1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LAB (US) | 2007-09-12 | — | — | EP | disclosed |