Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.64 |
| ▸ | INSR | P06213 | 7/20 | 0.64 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.62 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.57 |
| ▸ | IGF1R | P08069 | 2/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382126 | 0.78 | EGFR (0.70) | ALKINSRZAP70EGFRIGF1R | |
| SCHEMBL1080877 | 0.77 | ULK1 (0.65) | ALKINSRZAP70LRRK2EGFR | |
| SCHEMBL18650996 | 0.77 | ALK (0.85) | ALKINSRZAP70LRRK2EGFR | |
| SCHEMBL12311873 | 0.76 | LRRK2 (1.00) | ALKINSRZAP70LRRK2EGFR | |
| SCHEMBL4106591 | 0.76 | ZAP70 (0.77) | ALKINSRZAP70LRRK2EGFR | |
| SCHEMBL4100983 | 0.75 | ZAP70 (0.79) | ALKINSRZAP70LRRK2EGFR | |
| SCHEMBL12780145 | 0.75 | ZAP70 (0.85) | ALKINSRZAP70LRRK2EGFR | |
| SCHEMBL28447693 | 0.75 | ALK (0.85) | ALKINSRZAP70LRRK2EGFR | |
| SCHEMBL29429981 | 0.75 | EGFR (1.00) | ALKINSRZAP70LRRK2EGFR | |
| SCHEMBL1460537 | 0.75 | EGFR (1.00) | ALKINSRZAP70LRRK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784392-A2 | PYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021454-A2 | PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2006-03-02 | — | — | WO | disclosed |