Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL527890 | 0.90 | MAPT (0.62) | MAPTNPSR1HTTKMT2AMEN1 | |
| SCHEMBL529092 | 0.90 | KMT2A (0.59) | MAPTNPSR1HTTKMT2AMEN1 | |
| SCHEMBL529523 | 0.90 | MAPT (0.56) | MAPTNPSR1HTTKMT2AMEN1 | |
| SCHEMBL528800 | 0.89 | MAPT (0.62) | MAPTNPSR1HTTKMT2AMEN1 | |
| SCHEMBL528007 | 0.89 | MAPT (0.62) | MAPTNPSR1HTTKMT2AMEN1 | |
| SCHEMBL528092 | 0.88 | MAPT (0.70) | MAPTNPSR1HTTKMT2AMEN1 | |
| SCHEMBL528058 | 0.87 | MEN1 (0.67) | MAPTNPSR1HTTKMT2AMEN1 | |
| SCHEMBL529360 | 0.87 | LMNA (0.67) | MAPTNPSR1HTTKMT2AMEN1 | |
| SCHEMBL528222 | 0.86 | MAPT (0.66) | MAPTNPSR1HTTKMT2AMEN1 | |
| SCHEMBL528907 | 0.86 | MAPT (0.64) | MAPTNPSR1HTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |