Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 13/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16017546 | 0.83 | NCF1 (0.58) | NCF1CHRM4HTTALDH1A1NPSR1 | |
| SCHEMBL21190487 | 0.80 | NCF1 (0.67) | NCF1CHRM4HTTALDH1A1NPSR1 | |
| SCHEMBL3848428 | 0.79 | NCF1 (0.56) | NCF1CHRM4ALDH1A1 | |
| SCHEMBL1544187 | 0.79 | NCF1 (0.62) | NCF1CHRM4HTTALDH1A1NPSR1 | |
| SCHEMBL22715673 | 0.78 | NCF1 (0.76) | NCF1HTTALDH1A1NPSR1 | |
| SCHEMBL29472100 | 0.78 | NCF1 (0.76) | NCF1HTTALDH1A1NPSR1 | |
| SCHEMBL3847734 | 0.77 | NCF1 (0.70) | NCF1HTTALDH1A1NPSR1MEN1 | |
| SCHEMBL21173526 | 0.77 | NCF1 (0.62) | NCF1CHRM4HTT | |
| SCHEMBL731691 | 0.76 | NCF1 (0.74) | NCF1HTTALDH1A1NPSR1 | |
| SCHEMBL3845241 | 0.76 | NCF1 (0.61) | NCF1CHRM4ALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |