Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 10/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | IL6 | P05231 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3749079 | 0.82 | MCHR1 (0.45) | FLT3MAPTRXFP1THRBTP53 | |
| SCHEMBL3753843 | 0.77 | MAPT (0.48) | MAPTRXFP1THRBTP53DGAT1 | |
| Hydrochloric Acid SCHEMBL3754000 | 0.76 | MAPT (0.47) | MAPTRXFP1THRBTP53DGAT1 | |
| SCHEMBL5296164 | 0.75 | MAPT (0.46) | MAPTRXFP1THRBTP53IL6 | |
| SCHEMBL19432575 | 0.71 | TP53 (0.76) | MAPTRXFP1THRBTP53PTGS2 | |
| SCHEMBL3746171 | 0.71 | MAPT (0.51) | FLT3MAPTRXFP1THRBTP53 | |
| SCHEMBL3754747 | 0.69 | MCHR1 (0.63) | MAPTRXFP1THRBTP53MCHR1 | |
| Hydrochloric Acid SCHEMBL5326025 | 0.68 | MAPT (0.51) | MAPTRXFP1THRBTP53PTGS2 | |
| SCHEMBL30860341 | 0.68 | FLT3 (0.51) | FLT3DGAT1MCHR1NR1H4 | |
| SCHEMBL5290458 | 0.68 | MAPT (0.52) | MAPTTHRBTP53MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006066173-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-06-22 | — | — | WO | disclosed |