Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | IL6 | P05231 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5326025 | 0.93 | MAPT (0.51) | MAPTRXFP1THRBTP53PTGS2 | |
| SCHEMBL3749086 | 0.83 | MAPT (0.46) | MAPTRXFP1THRBTP53PTGS2 | |
| SCHEMBL3753848 | 0.77 | MAPT (0.53) | MAPTRXFP1THRBTP53PTGS2 | |
| Hydrochloric Acid SCHEMBL3754012 | 0.77 | MAPT (0.52) | MAPTRXFP1THRBTP53PTGS2 | |
| SCHEMBL5296148 | 0.75 | FLT3 (0.45) | MAPTRXFP1THRBTP53PTGS2 | |
| SCHEMBL19432575 | 0.71 | TP53 (0.76) | MAPTRXFP1THRBTP53PTGS2 | |
| SCHEMBL5246428 | 0.69 | MAPT (0.52) | MAPTTHRBTP53ALDH1A1KDM4E | |
| SCHEMBL3748630 | 0.69 | HDAC3 (0.42) | — | |
| SCHEMBL3754747 | 0.68 | MCHR1 (0.63) | MAPTRXFP1THRBTP53NR1H4 | |
| SCHEMBL3749079 | 0.67 | MCHR1 (0.45) | MAPTRXFP1THRBTP53PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006066173-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-06-22 | — | — | WO | disclosed |