Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5285908 | 0.91 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11DGAT1 | |
| SCHEMBL5289299 | 0.82 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5295739 | 0.80 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11DGAT1 | |
| SCHEMBL5281275 | 0.79 | BUB1 (0.39) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5286643 | 0.78 | MAPK1 (0.47) | MAPK14MAPK13MAPK12MAPK11DGAT1 | |
| SCHEMBL5281273 | 0.74 | MAPK14 (0.60) | MAPK14 | |
| SCHEMBL3047663 | 0.73 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3058616 | 0.73 | MAPK14 (0.51) | MAPK14 | |
| SCHEMBL3050591 | 0.68 | MAPK14 (0.68) | MAPK14MAPK11 | |
| SCHEMBL3050076 | 0.68 | MAOA (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007000337-A1 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | claimed |
| WO-2007000337-A1 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | disclosed |