Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5289299 | 0.81 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5295739 | 0.79 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11DGAT1 | |
| SCHEMBL5286182 | 0.79 | MAPK1 (0.51) | MAPK1TDP1ALDH1A1CASP7L3MBTL1 | |
| SCHEMBL4225375 | 0.79 | MAPK14 (0.65) | MAPK1TDP1ALDH1A1CASP7L3MBTL1 | |
| SCHEMBL5299097 | 0.78 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11DGAT1 | |
| SCHEMBL5285908 | 0.76 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11DGAT1 | |
| SCHEMBL2986244 | 0.76 | MAPK1 (0.54) | MAPK1TDP1ALDH1A1CASP7L3MBTL1 | |
| SCHEMBL5300161 | 0.74 | ALDH3A1 (0.46) | MAPK1TDP1ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL23059073 | 0.73 | MAPK14 (0.61) | MAPK14 | |
| SCHEMBL23058982 | 0.73 | MAPK14 (0.63) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007000337-A1 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | disclosed |