Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.64 |
| ▸ | RAB9A | P51151 | 11/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856396 | 0.84 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL12338586 | 0.80 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL13405942 | 0.80 | LMNA (0.72) | SMN1; SMN2TP53LMNAPKM | |
| SCHEMBL1055062 | 0.80 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL14147581 | 0.80 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL1049736 | 0.79 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL856031 | 0.79 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL3429444 | 0.78 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL10858025 | 0.78 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL7692504 | 0.78 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007017267-A2 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-02-15 | — | — | WO | disclosed |