Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 20/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 19/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28329578 | 0.85 | SLC6A4 (0.39) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL3635111 | 0.81 | SLC6A4 (0.35) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL3635108 | 0.81 | SLC6A4 (0.35) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL29017156 | 0.80 | GPR119 (0.38) | SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL18142028 | 0.79 | SLC6A4 (0.35) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL529417 | 0.79 | RPLP1 (0.36) | KCNH2 | |
| SCHEMBL529544 | 0.79 | RPLP1 (0.36) | KCNH2 | |
| SCHEMBL2597129 | 0.79 | EP300 (0.34) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL26697116 | 0.78 | SLC6A4 (0.34) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4439873 | 0.77 | SLC6A4 (0.36) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |