Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.34 |
| ▸ | TACR1 | P25103 | 5/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29017156 | 0.85 | GPR119 (0.38) | SLC6A4SLC6A2SLC6A3TACR1PLAT | |
| SCHEMBL26697116 | 0.83 | SLC6A4 (0.34) | SLC6A4SLC6A2SLC6A3TACR1PLAT | |
| SCHEMBL529996 | 0.79 | SLC6A4 (0.36) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL28329578 | 0.76 | SLC6A4 (0.39) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL7956398 | 0.74 | SLC6A4 (0.34) | SLC6A4SLC6A2SLC6A3TACR1KCNH2 | |
| SCHEMBL18613658 | 0.73 | EHMT2 (0.32) | SLC6A4TACR1PLAT | |
| SCHEMBL27884240 | 0.72 | SMN1; SMN2 (0.47) | — | |
| SCHEMBL4253844 | 0.72 | HCAR3 (0.40) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL27774385 | 0.72 | ELANE (0.35) | SLC6A4TACR1 | |
| SCHEMBL12469312 | 0.72 | SLC6A2 (0.46) | SLC6A4SLC6A2SLC6A3TACR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103080101-A | Piperidinyl-substituted lactams as GPR119 modulators | ARRAY BIOPHARMA INC | 2013-05-01 | — | — | CN | disclosed |
| EP-2571864-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |