Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 19/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788254 | 0.91 | DGAT1 (0.62) | DGAT1NPC1RAB9A | |
| SCHEMBL5302124 | 0.85 | DGAT1 (0.71) | DGAT1NPC1RAB9ASOAT1 | |
| SCHEMBL5248671 | 0.81 | DGAT1 (0.64) | DGAT1NPC1RAB9A | |
| SCHEMBL5302933 | 0.81 | DGAT1 (0.57) | DGAT1NPC1RAB9A | |
| SCHEMBL4788842 | 0.81 | DGAT1 (0.62) | DGAT1NPC1RAB9ASOAT1 | |
| SCHEMBL3536787 | 0.81 | DGAT1 (0.75) | DGAT1NPC1RAB9A | |
| SCHEMBL18236237 | 0.80 | DGAT1 (0.55) | DGAT1NPC1RAB9A | |
| SCHEMBL4787021 | 0.80 | DGAT1 (0.65) | DGAT1SOAT1 | |
| SCHEMBL5307790 | 0.80 | DGAT1 (0.61) | DGAT1NPC1RAB9ASOAT1 | |
| SCHEMBL3928136 | 0.80 | DGAT1 (0.69) | DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833806-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006064189-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |