Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12887986 | 0.86 | NAMPT (0.56) | GAAALDH1A1POLBNAMPT | |
| SCHEMBL1179500 | 0.76 | GAA (0.45) | GAAALDH1A1POLBTLR7RAB9A | |
| SCHEMBL16600343 | 0.76 | STAT3 (0.51) | RAB9ANPC1SMN1; SMN2STAT3NAMPT | |
| SCHEMBL29476654 | 0.73 | METAP1 (0.46) | RAB9ANPC1SMN1; SMN2NAMPT | |
| SCHEMBL623831 | 0.73 | METAP1 (0.46) | RAB9ANPC1SMN1; SMN2NAMPT | |
| SCHEMBL1155947 | 0.72 | LMNA (0.46) | GAAALDH1A1POLBTLR7RAB9A | |
| SCHEMBL21358025 | 0.71 | GABRA1 (0.42) | ALDH1A1POLBRAB9ANPC1 | |
| SCHEMBL24602868 | 0.70 | HDAC1 (0.60) | CA12CA1CA2CA9CA14 | |
| SCHEMBL456000 | 0.69 | MEN1 (0.44) | GAAALDH1A1POLBRAB9ANPC1 | |
| SCHEMBL16879880 | 0.69 | GAA (0.47) | GAAALDH1A1POLBRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012015693-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-02-02 | — | — | WO | disclosed |