Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.52 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.52 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246035 | 1.00 | CTSS (0.56) | CTSSCTSKSIRT2SIRT1SIRT3 | |
| SCHEMBL5307836 | 0.94 | SIRT5 (0.58) | CTSSCTSKSIRT2SIRT1SIRT3 | |
| SCHEMBL8247697 | 0.94 | SIRT5 (0.58) | CTSSCTSKSIRT2SIRT1SIRT3 | |
| SCHEMBL8245893 | 0.94 | SIRT5 (0.58) | CTSSCTSKSIRT2SIRT1SIRT3 | |
| SCHEMBL20253483 | 0.86 | HDAC8 (0.50) | CTSSCTSKSIRT2SIRT1SIRT5 | |
| SCHEMBL6290849 | 0.86 | MAPT (0.52) | CTSSCTSKSIRT2SIRT1SIRT3 | |
| SCHEMBL8244805 | 0.85 | SIRT5 (0.59) | SIRT2SIRT1SIRT3SIRT5SYK | |
| SCHEMBL5308048 | 0.85 | SIRT5 (0.59) | SIRT2SIRT1SIRT3SIRT5SYK | |
| SCHEMBL5441822 | 0.83 | SYK (0.63) | CTSSCTSKSIRT2SIRT1SYK | |
| SCHEMBL16274170 | 0.83 | SYK (0.63) | CTSSCTSKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007027742-A2 | SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-03-08 | — | — | WO | disclosed |