Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | BCL9 | O00512 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306561 | 0.81 | MET (0.43) | METKDRAXLHIPK4 | |
| SCHEMBL1269377 | 0.74 | MET (0.58) | METKDRAXL | |
| SCHEMBL1269426 | 0.72 | MET (0.49) | METKDRAXL | |
| SCHEMBL5157575 | 0.69 | AXL (0.44) | METKDRAXLHIPK4 | |
| SCHEMBL3552329 | 0.69 | MET (0.69) | METKDRAXL | |
| SCHEMBL1137174 | 0.68 | MET (0.48) | METKDRAXL | |
| SCHEMBL1137376 | 0.68 | KDR (0.64) | METKDRAXLHIPK4 | |
| SCHEMBL29757310 | 0.68 | GCK (0.56) | METKDRAXL | |
| SCHEMBL23913769 | 0.66 | P2RX3 (0.53) | — | |
| SCHEMBL29757282 | 0.66 | P2RX3 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007035428-A1 | MET KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-03-29 | — | — | WO | disclosed |