Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP10 | P09238 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5295939 | 0.88 | HCAR2 (0.51) | KDM4EALDH1A1HCAR2HDAC1MMP2 | |
| SCHEMBL5061223 | 0.85 | KDM4E (0.62) | KDM4ENPC1RAB9AMAPK8MAPK10 | |
| SCHEMBL5303071 | 0.84 | KDM4E (0.50) | KDM4ENPC1RAB9AMAPK8MAPK10 | |
| SCHEMBL5300760 | 0.82 | ALDH1A1 (0.56) | KDM4ENPC1RAB9AMAPK8MAPK10 | |
| SCHEMBL5296892 | 0.81 | HCAR2 (0.67) | KDM4ERAB9AMAPK8MAPK10MAPK9 | |
| SCHEMBL5302379 | 0.81 | KDM4E (0.54) | KDM4ENPC1RAB9AMAPK8MAPK10 | |
| SCHEMBL5306189 | 0.80 | HCAR2 (0.53) | KDM4ENPC1RAB9AMAPK8MAPK10 | |
| SCHEMBL5302182 | 0.80 | KDM4E (0.49) | KDM4ENPC1RAB9AMAPK8MAPK10 | |
| SCHEMBL5297607 | 0.80 | HCAR2 (0.62) | KDM4ENPC1RAB9AMAPK8MAPK10 | |
| SCHEMBL14609699 | 0.80 | HCAR2 (0.64) | KDM4ENPC1RAB9AMAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |