Ornithine

Ornithine

SCHEMBL53033

CCC(N)(N)C(=O)O.NCCC[C@H](N)C(=O)O

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GSR P00390 1/20 0.58
NOS1 P29475 7/20 0.42
DDAH1 O94760 3/20 0.42
NOS2 P35228 7/20 0.41
NOS3 P29474 5/20 0.41
CYP2C19 P33261 2/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
ARG2 P78540 4/20 0.41
ARG1 P05089 3/20 0.41
CYP1A2 P05177 2/20 0.40
TSHR P16473 2/20 0.40
CYP3A4 P08684 1/20 0.40
GLA P06280 1/20 0.40
NFKB1 P19838 1/20 0.40
APEX1 P27695 1/20 0.40
BLM P54132 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ornithine Aketoglutarate SCHEMBL53032 1.00 GSR (0.58) GSRNOS1DDAH1NOS2NOS3
Lysine SCHEMBL3821051 0.92 GSR (0.62) GSRNOS1DDAH1NOS2NOS3
Lysine SCHEMBL3821052 0.92 GSR (0.62) GSRNOS1DDAH1NOS2NOS3
Ornithine Aketoglutarate SCHEMBL3000503 0.84 GSR (0.64) GSRNOS1DDAH1NOS2NOS3
Ornithine SCHEMBL6757036 0.84 GSR (0.64) GSRNOS1DDAH1NOS2NOS3
Ornithine SCHEMBL3000505 0.84 GSR (0.64) GSRNOS1DDAH1NOS2NOS3
Diaminopropanoic Acid SCHEMBL28533274 0.82 SLC1A3 (0.39) GSRCYP1A2
Ornithine Aketoglutarate SCHEMBL28452040 0.81 GSR (0.78) GSRNOS1DDAH1NOS2NOS3
Ornithine SCHEMBL3443860 0.81 GSR (0.78) GSRNOS1DDAH1NOS2NOS3
Ornithine SCHEMBL624782 0.81 GSR (0.86) GSRNOS1NOS2NOS3CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1578 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12037593-B2 Methods and means for modifying the alkaloid content of plants BRITISH AMERICAN TOBACCO (INVESTMENTS) LIMITED (GB) 2024-07-16 US disclosed
EP-3500670-B1 METHOD FOR SELECTING TARGET SEQUENCES FOR GUIDE RNA OF CRISPR SYSTEMS BROAD INST INC (US) 2024-07-10 EP disclosed
EP-3500671-B1 METHOD OF SELECTING TARGET SEQUENCES FOR THE DESIGN OF GUIDE RNAS BROAD INST INC (US) 2024-07-10 EP disclosed
WO-2024145191-A2 METHODS FOR PRODUCING PLANT BASED FOOD ALTERNATIVES INTERNATIONAL N&H DENMARK APS (DK) 2024-07-04 WO disclosed
US-12023391-B2 Alpha(v)beta(6) integrin-binding peptides and methods of use thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-07-02 US disclosed
US-20240209359-A1 METHODS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF THE BROAD INSTITUTE, INC. (US) 2024-06-27 US disclosed
US-12018275-B2 Delivery and use of the CRISPR-CAS systems, vectors and compositions for hepatic targeting and therapy THE BROAD INSTITUTE, INC. (US) 2024-06-25 US disclosed
US-20240191223-A1 TYPE VI CRISPR ORTHOLOGS AND SYSTEMS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-06-13 US disclosed
US-20240180172-A1 AMYLASE POLYPEPTIDES WITH IMPROVED PROPERTIES DUPONT NUTRITION BIOSCI APS (DK) 2024-06-06 US disclosed
US-20240182928-A1 NOVEL CRISPR ENZYMES AND SYSTEMS SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY (RU) 2024-06-06 US disclosed
WO-2001077380-A2 METHOD FOR PREDICTING PREDISPOSITION TO A DISEASE ASSOCIATED WITH MUTATIONS IN A RPGR GENE MEDICAL RESEARCH COUNCIL (GB) 2001-10-18 WO disclosed
EP-1135410-A2 ANTENNAPEDIA HOMEODOMAIN HELIX 3 DERIVED TRANSLOCATION VECTORS Cyclacel Limited (GB) 2001-09-26 EP disclosed
EP-1118858-A2 Assay method Pfizer Limited (GB) 2001-07-25 EP disclosed
EP-1108360-A1 Method of improving dough and bread quality DANISCO A/S (DK) 2001-06-20 EP disclosed
WO-2001039602-A1 METHOD OF IMPROVING DOUGH AND BREAD QUALITY DANISCO A/S (DK) 2001-06-07 WO disclosed
EP-1097707-A1 Treatment of female sexual dysfunction Pfizer Limited (GB) 2001-05-09 EP disclosed
EP-1097706-A1 Phosphodiesterase inhibitors for the treatment of female sexual dysfunction Pfizer Limited (GB) 2001-05-09 EP disclosed
EP-1097718-A1 NPY antagonists for the treatment of female sexual dysfunction Pfizer Limited (GB) 2001-05-09 EP disclosed
EP-1097719-A1 NEP inhibitors for the treatment of female sexual dysfunction Pfizer Limited (GB) 2001-05-09 EP disclosed
WO-2000029427-A2 ANTENNAPEDIA HOMEODOMAIN HELIX 3 DERIVED TRANSLOCATION VECTORS CYCLACEL LIMITED (GB) 2000-05-25 WO disclosed