Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.62 |
| ▸ | NOS1 | P29475 | 8/20 | 0.44 |
| ▸ | NOS2 | P35228 | 8/20 | 0.44 |
| ▸ | NOS3 | P29474 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ARG2 | P78540 | 4/20 | 0.41 |
| ▸ | ARG1 | P05089 | 3/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL3821051 | 1.00 | GSR (0.62) | GSRNOS1NOS2NOS3CYP1A2 | |
| Ornithine Aketoglutarate SCHEMBL53032 | 0.92 | GSR (0.58) | GSRNOS1NOS2NOS3CYP1A2 | |
| Ornithine SCHEMBL53033 | 0.92 | GSR (0.58) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL7048440 | 0.83 | GSR (0.71) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL7048439 | 0.83 | GSR (0.71) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL5060018 | 0.83 | GSR (0.91) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL4641859 | 0.83 | GSR (0.91) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL31644218 | 0.83 | GSR (0.91) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL31039861 | 0.83 | GSR (0.91) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL7040784 | 0.82 | GSR (0.74) | GSRNOS1NOS2NOS3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089425-A2 | ANTI-ANGIOGENIC COMPOUNDS | CovX Technologies Ireland Limited (IE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008056346-A2 | ANTI-ANGIOGENIC COMPOUNDS | COVX TECHNOLOGIES IRELAND LIMITED (IE) | 2008-05-15 | — | — | WO | disclosed |