SCHEMBL5305271

SCHEMBL5305271

CC1CNCCN1c1c(F)ccc(-c2ccccc2)c1F

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 11/20 0.40
HTR2B P41595 7/20 0.40
HTR2A P28223 5/20 0.37
ALOX5AP P20292 4/20 0.36
FEN1 P39748 4/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
HTR1A P08908 1/20 0.35
HTR7 P34969 1/20 0.35
HTR5A P47898 1/20 0.35
HTR6 P50406 1/20 0.35
DPP4 P27487 1/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35
GSK3B P49841 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4887832 0.81 HTR2C (0.52) HTR2CHTR2BHTR2AHTR1AHTR7
SCHEMBL4881120 0.81 HTR2C (0.52) HTR2CHTR2BHTR2AHTR1AHTR7
SCHEMBL4884861 0.81 HTR2C (0.52) HTR2CHTR2BHTR2AHTR1AHTR7
SCHEMBL4890361 0.80 RAD52 (0.43) HTR2CHTR2BHTR2AALOX5APFEN1
SCHEMBL4885558 0.80 RAD52 (0.43) HTR2CHTR2BHTR2AALOX5APFEN1
SCHEMBL4885161 0.80 RAD52 (0.43) HTR2CHTR2BHTR2AALOX5APFEN1
SCHEMBL5294302 0.76 HTR7 (0.53) HTR2CHTR2BHTR2AHTR1AHTR7
SCHEMBL5630648 0.75 LATS1 (0.41) HTR2CHTR2BHTR2AALOX5APFEN1
SCHEMBL5633086 0.75 LATS1 (0.41) HTR2CHTR2BHTR2AALOX5APFEN1
SCHEMBL5632580 0.75 LATS1 (0.41) HTR2CHTR2BHTR2AALOX5APFEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006065706-A9 N-BIARYL AND N-ARYLHETEROARYL 2-SUBSTITUTED PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARM INC (US) 2007-07-26 WO claimed
EP-1831188-A1 N-BIARYL AND N-ARYLHETEROARYL 2-SUBSTITUTED PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2007-09-12 EP disclosed
WO-2006065706-A9 N-BIARYL AND N-ARYLHETEROARYL 2-SUBSTITUTED PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARM INC (US) 2007-07-26 WO disclosed
WO-2006065706-A1 N-BIARYL AND N-ARYLHETEROARYL 2-SUBSTITUTED PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2006-06-22 WO disclosed